Patient Management

• Common adverse effects include elevated blood urea nitrogen and creatinine, asymptomatic mild-to-moderate hypocalcemia, and transient hypophosphatemia
  
  
• Ganite should not be administered to patients with severe renal impairment (serum creatinine > 2.5 mg/dL); monitoring of renal status is recommended in patients with moderately impaired renal function
  
  
• Though no direct link has been established to Ganite, potential adverse reactions such as a decrease in serum bicarbonate, anemia, decrease in blood pressure, and rarely (< 1%) optic neuritis, tinnitus, and partial loss of auditory acuity have been reported
  
  
• The safety and efficacy of subcutaneous administration (see Drug Interactions section of the Prescribing Information) or retreatment with Ganite has not been established.