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Important Therapy for a Serious Complication
Hypercalcemia is the most common, serious metabolic disorder in patients with
cancer.
4-7
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Hypercalcemia occurs in as many as 10% to 20% of cancer patients.
1
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Certain malignancies, including non-small cell lung cancer, breast cancer, multiple myeloma,
and squamous cell cancers, are associated with a higher incidence of hypercalcemia.
1-3
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Cancer-related hypercalcemia can often go undiagnosed, as many patients may exhibit vague and
nonspecific signs and symptoms or signs and symptoms can be alternatively attributed to
anti-cancer treatment, brain metastases, or progressive disease.
6,
8
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In one recent prospective study of hospitalized cancer patients with hypercalcemia attributable
to their malignancy, 63% of patients received no specific therapy for cancer-related hypercalcemia,
and 75% were not adequately rehydrated.
8
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Because effective treatment can normalize serum calcium concentrations, with substantial
improvement of symptoms and quality of life, patients at high risk of cancer-related hypercalcemia
should be closely monitored to allow early detection and prompt, appropriate intervention.
7-9
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